Molecular Formula | C8H8FN.HCl |
Melting Point | 212-222℃ |
Storage Condition | 2-8°C |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
UN IDs | UN 3335 |
WGK Germany | 3 |
use | 4-fluoroisoindoline hydrochloride is a heterocyclic derivative, which can be used as an intermediate in pharmaceutical synthesis, used in pharmaceutical experimental research and pharmaceutical synthesis. |
preparation method | synthesis of isoindoline compound 4-fluoroisoindoline hydrochloride, add 1, 2-dichlorobenzyl -3-fluorine (10 mmol,1.0 eq), methylamine solution (10 mmol,1.0 eq) and triethylamine (20 mmol,2.0eq) were stirred at 80 ℃ for 1 h. The reaction was monitored by thin layer chromatography (TLC). after the reaction is completed, reduce the temperature in the reaction system to room temperature, add 30 mL of petroleum ether, stir for 10 min, filter to obtain filtrate, vacuum evaporation to remove the petroleum ether to obtain the target compound 4-fluoroisoindoline hydrochloride. |